Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells
| Autor: | Jayna M. Rose, Kenneth L. Audus |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Cell Membrane Permeability Endothelium Physiology Endocytic cycle Biological Transport Active Blood–brain barrier Biochemistry Arsenicals Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Phenylarsine oxide Enzyme Inhibitors Monensin Microvessel Cells Cultured Receptors Angiotensin Angiotensin II Microcirculation Receptor-mediated endocytosis medicine.anatomical_structure chemistry Transcytosis Blood-Brain Barrier Cerebrovascular Circulation cardiovascular system Cattle Endothelium Vascular hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 19(6) |
| ISSN: | 0196-9781 |
| Popis: | Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K m of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [ 3 H]Ang II transport was found to be inhibited by excess unlabeled Ang II, by the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2–8) and-(3–8) were shown to significantly increase the transport of Ang II. These results demonstrate for the first time the receptor-mediated transcytosis of Ang II across brain microvessel endothelium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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