TLR9 Polymorphisms Are Associated with Altered IFN-γ Levels in Children with Cerebral Malaria
| Autor: | Jennifer A. Greene, Nadia A. Sam-Agudu, Peter A. Zimmerman, Michael J. Boivin, James W. Kazura, Melissa A. Riedesel, Tracy L. Bergemann, Lisa A. Schimmenti, Chandy C. John, Robert O. Opoka |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Genotype medicine.medical_treatment Malaria Cerebral Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Interferon-gamma Virology parasitic diseases medicine Humans Interferon gamma Allele Child Tumor Necrosis Factor-alpha Articles medicine.disease Toll-Like Receptor 2 Toll-Like Receptor 4 TLR2 Infectious Diseases Cytokine Gene Expression Regulation Cerebral Malaria Child Preschool Toll-Like Receptor 9 Immunology Parasitology Female Malaria medicine.drug |
| Popis: | Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at -1237 or the G allele at 1174 had higher levels of IFN-gamma than those without these alleles (P = 0.03 and 0.008, respectively). The TLR9 SNPs were not associated with altered IFN-gamma levels in children with UM or altered TNF-alpha levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection. |
| Databáze: | OpenAIRE |
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