Metallaphotoredox-Enabled Construction of the P(O)–N Bond from Aromatic Amines and P(O)–H Compounds

Autor:	Kai-Cheng Yu, Hai Li, Yuan-Hong Tu, Hui Zhao, Xiang-Guo Hu
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:9130-9134
ISSN:	1523-7052 1523-7060
Popis:	We have developed a dual copper/photoredox-catalyzed approach for the construction of the P(O)-N bond from commercially available aromatic amines and P(O)-H compounds. This metallaphotoredox method avoids toxic or corrosive reagents and does not require prefunctionalized substrates. The reaction has a broad substrate scope and is suitable for the synthesis of phosphonamides and phosphinamides, thus complementing the previous nonphotochemical approaches. The reaction is amenable to the direct modification of drug molecules and can be conducted on a gram scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8f11200d63329173746bfae1d0d9e0 https://doi.org/10.1021/acs.orglett.2c03860 Zobrazit plný text záznamu