Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations
| Autor: | Carmelo Salpietro, Caterina Cuppari, Sara Manti |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Immunology Histamine Antagonists Clinical practice Guidelines 03 medical and health sciences 0302 clinical medicine Risk Factors Anti-Allergic Agents Health care Humans Immunology and Allergy Medicine Practice Patterns Physicians' Child 030223 otorhinolaryngology Adverse effect Intensive care medicine Children business.industry Standard treatment General Medicine Guideline Clinical trial Clinical Practice 030228 respiratory system Practice Guidelines as Topic Antihistamine updosing Second-generation antihistamines Female Antihistamine business Pediatric population |
| Zdroj: | International Archives of Allergy and Immunology. 178:93-96 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000492636 |
| Popis: | The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Furthermore, a critical use of such guidelines should be done to improve the knowledge in CSU, especially in the pediatric population. |
| Databáze: | OpenAIRE |
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