Long-term prognostic effect of hormone receptor subtype on breast cancer
| Autor: | Jongjin Kim, Sook Young Jeon, Jeong Hwan Park, Jiwoong Jung, Kyu Ri Hwang, Su jin Kim, Eun Youn Roh, Ki Tae Hwang, Jin Hyun Park, Byoung Hyuck Kim |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine End results Cancer Research medicine.medical_specialty Prognostic factor Seer database Estrogen receptor Breast Neoplasms Favorable prognosis Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Progesterone receptor medicine Humans Aged Aged 80 and over Chemistry Middle Aged Prognosis medicine.disease Survival Analysis 030104 developmental biology Endocrinology Receptors Estrogen Oncology Hormone receptor 030220 oncology & carcinogenesis Female Receptors Progesterone SEER Program |
| Zdroj: | Breast Cancer Research and Treatment. 179:139-151 |
| ISSN: | 1573-7217 0167-6806 |
| Popis: | To determine the long-term prognostic role of hormone receptor subtype in breast cancer using surveillance, epidemiology, and end results (SEER) database. Data of 810,587 female operable invasive breast cancer patients from SEER database with a mean follow-up period of 94.2 months (range, 0–311 months) were analyzed. Hormone receptor subtype was classified into four groups based on estrogen receptor (ER) and progesterone receptor (PR) statuses: ER(+)/PR(+), ER(+)/PR(−), ER(−)/PR(+), and ER(−)/PR(−). Numbers of subjects with ER(+)/PR(+), ER(+)/PR(−), ER(−)/PR(+), ER(−)/PR(−), and unknown were 496,279 (61.2%), 86,858 (10.7%), 11,545 (1.4%), 135,441 (16.7%), and 80,464 (9.9%), respectively. The ER(+)/PR(+) subtype showed the best breast-cancer-specific survival, followed by ER(+)/PR(−), ER(−)/PR(+), and ER(−)/PR(−) subtypes in the respective order (all p |
| Databáze: | OpenAIRE |
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