Role of Endogenous and Exogenous Corticosterone on Behavioral and Cognitive Responses to Low-Pressure Blast Wave Exposure
| Autor: | Jay R. Hoffman, Hagit Cohen, Zeev Kaplan, Michael A. Matar, Omri Ram, Oren Sadot, Gal Ifergane, Amitai Zuckerman |
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| Rok vydání: | 2018 |
| Předmět: |
Male
030506 rehabilitation Traumatic brain injury Anti-Inflammatory Agents Endogeny Rats Sprague-Dawley Stress Disorders Post-Traumatic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Corticosterone Blast Injuries mental disorders medicine Animals Blast wave Brain Concussion business.industry Cognition Explosive blast medicine.disease Rats chemistry Pressure blast Neurology (clinical) Animal studies 0305 other medical science business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurotrauma. 36(2) |
| ISSN: | 1557-9042 |
| Popis: | The complex interactions and overlapping symptoms of comorbid post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) induced by an explosive blast wave have become a focus of attention in recent years, making clinical distinction and effective intervention difficult. Because dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is thought to underlie trauma-related (psycho)pathology, we evaluated both the endogenous corticosterone response and the efficacy of exogenous hydrocortisone treatment provided shortly after blast exposure. We employed a controlled experimental blast-wave paradigm in which unanesthetized animals were exposed to visual, auditory, olfactory, and tactile effects of an explosive blast wave produced by exploding a thin copper wire. Endogenous corticosterone concentrations were evaluated at different time points (before, and 3 h, 5 h and 17 days) after blast exposure. Subsequently, the efficacy of exogenous hydrocortisone (25 mg/kg |
| Databáze: | OpenAIRE |
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