Anti-HCV reactive volunteer blood donors distribution character and genotypes switch in Xi'an, China
| Autor: | Yaozhen Chen, Wen-li Sun, Min-quan Su, Xingbin Hu, Xiaoke Hao, Shijie Mu, Xianqing Zhang, Yu Shang, Qiaohong Yue |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
China
Blood transfusion Genotype Hepacivirus medicine.medical_treatment Population Blood Donors Enzyme-Linked Immunosorbent Assay lcsh:Infectious and parasitic diseases Seroepidemiologic Studies Virology medicine Humans lcsh:RC109-216 education Pathogen Volunteer education.field_of_study biology Transmission (medicine) Reverse Transcriptase Polymerase Chain Reaction Research virus diseases Hepatitis C Hepatitis C Antibodies biology.organism_classification medicine.disease digestive system diseases Infectious Diseases Immunology |
| Zdroj: | Virology Journal, Vol 7, Iss 1, p 186 (2010) Virology Journal |
| Popis: | HCV is prevailed in the world as well as in China. Blood transfusion is one of the most common transmission pathways of this pathogen. Although data of HCV infection character were reported during the past years, anti-HCV reactive profile of China donors was not fully clear yet. Furthermore, infection progress was found related to the HCV genotype. Different genotype led to different efficacy when interferon was introduced into HCV therapy. Here we provided character data of HCV infection in China blood donors from the year of 2000 to 2009. The infection rate in local donors was lower than general population and descended from 0.80% to 0.40% or so in recent years. About 83% HCV strains were categorized into genotypes 1b and 2a. But 1b subtype cases climbed and 2a subtype cases decreased. The current study threw more light on HCV infection of blood donors in China, at least in the Northern region. |
| Databáze: | OpenAIRE |
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