Effect of cardiomyoplasty on systolic and diastolic function
| Autor: | Fris J, Landymore Rw, John M. You |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac function curve medicine.medical_specialty Heart disease Systole Biopsy Cardiac Volume medicine.medical_treatment Muscle Fibers Skeletal Diastole Collateral Circulation Ventricular Function Left Dogs Ischemia Internal medicine Ventricular Pressure medicine Animals Cardiomyoplasty Muscle Skeletal Ligation Heart Failure business.industry Cardiac Pacing Artificial Stroke Volume General Medicine Stroke volume medicine.disease Elasticity body regions Disease Models Animal Preload Heart failure Cardiology Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 9:672-677 |
| ISSN: | 1010-7940 |
| Popis: | Although cardiomyoplasty has become a recognized treatment for end-stage heart failure, the effects of this procedure on systolic and diastolic function are still unclear. To determine the effects of paced and non-paced latissimus dorsi cardiomyoplasty on systolic and diastolic function, the maximal elastance of the left ventricle (E max ), stroke volume, preload recruitable stroke work and diastolic compliance were measured in an experimental heart failure model. Collateral blood vessels to the latissimus dorsi were ligated 2 weeks before cardiomyoplasty in order to reduce the risk of ischemic injury. Histological examination of muscle biopsies confirmed that the two-stage procedure preserved normal muscle architecture. The non-paced cardiomyoplasty wrap adversely affected both systolic and diastolic function. Paced Latissimus Dorsi during heart failure improved systolic function but had no measurable effect on diastolic function. Conclusions : 1. Non-paced, or unstimulated, latissimus dorsi cardiomyoplasty acutely impairs cardiac function. 2. Delayed cardiomyoplasty, 2 weeks after collateral ligation, prevents ischemic injury to the muscle flap. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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