Evaluation of androgen metabolism studies in human prostate cancer—Correlation with zinc levels
| Autor: | F.K. Habib |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
PCA3 medicine.medical_specialty Epidemiology Prostatic Hyperplasia Endogeny Prostate Internal medicine medicine Carcinoma Humans Endocrine system Testosterone Aged business.industry Androstenedione Public Health Environmental and Occupational Health Prostatic Neoplasms Cancer Dihydrotestosterone Radioimmunoassay Middle Aged medicine.disease Zinc medicine.anatomical_structure Endocrinology Androgens business |
| Zdroj: | Preventive Medicine. 9:650-656 |
| ISSN: | 0091-7435 |
| DOI: | 10.1016/0091-7435(80)90036-5 |
| Popis: | Standard radioimmunoassay and enzymatic techniques were used for the measurement of endogenous steroid levels and the evaluation of three specific enzymatic activities in prostate tissue from patients with benign prostatic hypertrophy (BPH) and carcinoma of the prostate (CaP). In order to develop new methods for the characterization of prostatic cancer, these parameters were also correlated to the zinc concentration found in the tissues. Our studies suggest that the malignant tissue was very distinct in all parameters examined and significant differences between the benign and cancerous prostate were observed: (a) differences in the enzymatic profiles—5α-reductase and 3α(β)-hydroxysteroid dehydrogenase decreased in cancer whereas 17β-hydroxyteroid dehydrogenase increased, (b) the excessively high levels of testosterone found in the malignant tissue, and (c) the inability of CaP to retain the zinc. Our studies also suggest that the endocrine activity of the gland is dependent upon the zinc concentration in the tissue and that these metallohormonal studies could be selectively used to discriminate between BPH and CaP. |
| Databáze: | OpenAIRE |
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