Mitochondrial Pathobiology and Metabolic Remodeling in Progression to Overt Systolic Heart Failure
| Autor: | Antoine H Chaanine, Patrice Delafontaine, Thierry H. LeJemtel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
Cell heart failure Review 030204 cardiovascular system & hematology Mitochondrion Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine oxidative capacity medicine 030304 developmental biology remodeling 0303 health sciences calcium business.industry Endoplasmic reticulum Cardiac myocyte General Medicine medicine.disease mitochondria medicine.anatomical_structure Ion homeostasis Heart failure business Neuroscience metabolism |
| Zdroj: | Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | The mitochondria are mostly abundant in the heart, a beating organ of high- energy demands. Their function extends beyond being a power plant of the cell including redox balance, ion homeostasis and metabolism. They are dynamic organelles that are tethered to neighboring structures, especially the endoplasmic reticulum. Together, they constitute a functional unit implicated in complex physiological and pathophysiological processes. Their topology in the cell, the cardiac myocyte in particular, places them at the hub of signaling and calcium homeostasis, making them master regulators of cell survival or cell death. Perturbations in mitochondrial function play a central role in the pathophysiology of myocardial remodeling and progression of heart failure. In this minireview, we summarize important pathophysiological mechanisms, pertaining to mitochondrial morphology, dynamics and function, which take place in compensated hypertrophy and in progression to overt systolic heart failure. Published work in the last few years has expanded our understanding of these important mechanisms; a key prerequisite to identifying therapeutic strategies targeting mitochondrial dysfunction in heart failure. |
| Databáze: | OpenAIRE |
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