Clinicopathological features and differential diagnosis of hepatocellular carcinoma in extrahepatic metastases

Autor: Jiye Zhu, Qiujing Song, Batubaiyin Xie, Zhao Li, Lihua Qian, Dingbao Chen
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
medicine.medical_treatment
Liver transplantation
Diagnostic Accuracy Study
Gastroenterology
Metastasis
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Glypicans
Antigens
Neoplasm
Internal medicine
differential diagnosis
medicine
Carcinoma
Humans
Neoplasm Metastasis
metastases
neoplasms
Lymph node
Aged
Retrospective Studies
Lung
Arginase
business.industry
Liver Neoplasms
Retrospective cohort study
hepatocellular carcinoma
General Medicine
Middle Aged
medicine.disease
digestive system diseases
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
Hepatocellular carcinoma
immunohistochemistry
Female
030211 gastroenterology & hepatology
alpha-Fetoproteins
Differential diagnosis
business
Biomarkers
Research Article
Zdroj: Medicine
ISSN: 1536-5964
0025-7974
Popis: Extrahepatic metastasis of hepatocellular carcinoma (HCC) may cause a diagnostic problem. All 195 cases of histologic and immunostained sections were reviewed retrospectively in one center. The expression of arginase-1 (Arg-1), hepatocyte paraffin-1 (HepPar-1), glypican-3 (GPC-3), and α-Fetoprotein (AFP) was evaluated. Eighty cases of metastatic tumors of the liver were also collected to verify their effectiveness. Totally 151 cases had previous history of HCC, in whom 49 had history of liver transplantation. Forty-four cases were diagnosed as metastatic HCC at initial presentation. The most common extrahepatic metastatic sites were bone (57%), followed by lung, lymph node, etc. Around 19 cases were positive for 1 marker, 22 were positive for 2 markers, 95 were positive for 3 markers, and 59 were positive for 4 markers. With the number of antibody increased in the panel, the negative cases decreased. The sensitivity of ARG, GPC-3, HepPar-1, and AFP was 82.6%, 89.2%, 83.6% and 53.8%, and the specificity was 98.3%, 94.8%, 96.2% and 100%, respectively. These data suggest that the panel of ARG-1, GPC-3, HepPar-1 and AFP has a high sensitivity and specificity to differentiate HCC from non-HCC. This study indicated that HCC should be considered when diagnosing metastasis of unclear origin. It is recommended to use the panel of ARG-1, GPC-3, HepPar-1 and AFP to differentiate HCC from non-HCC in extrahepatic metastasis, because of their sensitivity and specificity, especially in poorly differentiated lesions.
Databáze: OpenAIRE
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