Author Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
| Autor: | Michael Lloyd, R. Jay Mashl, Yvonne A. Evrard, Jeffrey A. Moscow, Jong Il Kim, Alana L. Welm, Michael A. Davies, Carol J. Bult, Jayamanna Wickramasinghe, Rania El Botty, Dennis A. Dean, Jessica Giordano, Anuj Srivastava, Sandra D. Scherer, Jacqueline Rosains, Christian Frech, Elisabetta Marangoni, Jeffrey H. Chuang, Ryan Jeon, Shunqiang Li, Matthew H. Bailey, Yun-Suhk Suh, Elodie Modave, Yuanxin Xi, Enzo Medico, Li Ding, Livio Trusolino, Adam Lafferty, Vito W. Rebecca, Han-Kwang Yang, Jing Wang, Annette T. Byrne, Xing Yi Woo, Alice C. O’Farrell, Claudio Isella, Li Chen, Brandi N. Davis-Dusenbery, James H. Doroshow, Sherri R. Davies, Diether Lambrechts, Jos Jonkers, Bingliang Fang, Charles Lee, Roebi de Bruijn, Violeta Serra, Jack A. Roth, Rajesh Patidar, Funda Meric-Bernstam, Petra ter Brugge, Andrew V. Kossenkov, Hyun-Soo Kim, Andrea Bertotti, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Ramaswamy Govindan, Francesco Galimi, Jelena Randjelovic, Zi-Ming Zhao, Bryan E. Welm, Hua Sun, Meenhard Herlyn, Michael T. Lewis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty DNA Copy Number Variations MEDLINE Biology Polymorphism Single Nucleotide Mice Text mining Internal medicine Databases Genetic Exome Sequencing Genetics medicine Animals Humans Neoplasm Metastasis Author Correction Cancer business.industry Published Erratum medicine.disease Xenograft Model Antitumor Assays Computational biology and bioinformatics Gene Expression Regulation Neoplastic business |
| Zdroj: | Nature Genetics |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting the accuracy of PDX modeling of human cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX models. CNA inferences based on DNA sequencing and microarray data displayed substantially higher resolution and dynamic range than gene expression-based inferences, and they also showed strong CNA conservation from PTs through late-passage PDXs. CNA recurrence analysis of 130 colorectal and breast PT/PDX-early/PDX-late trios confirmed high-resolution CNA retention. We observed no significant enrichment of cancer-related genes in PDX-specific CNAs across models. Moreover, CNA differences between patient and PDX tumors were comparable to variations in multiregion samples within patients. Our study demonstrates the lack of systematic copy number evolution driven by the PDX mouse host. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink