Phenotypic Characterization Of Regulatory T Cells From Antiretroviral-Naive Hiv-1-Infected People
| Autor: | Jules Colince Tchadji, Martin Samuel Sosso, Nadesh N. Nji, Flaurent T. Tchouangeu, Abel Lissom, Carole N. Sake, Godwin Nchinda, François-Xavier Etoa, Georgia N. Ambada, Claudine E. Ntsama, Loveline N. Ngu |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Anti-HIV Agents Immunology Human immunodeficiency virus (HIV) HIV Infections chemical and pharmacologic phenomena Biology CD38 Lymphocyte Activation medicine.disease_cause Immunotherapy Adoptive T-Lymphocytes Regulatory Immunophenotyping 03 medical and health sciences 0302 clinical medicine Immune system Antigens CD T-Lymphocyte Subsets immune system diseases medicine Antiretroviral naive Humans Immunology and Allergy Cameroon 030212 general & internal medicine Effector virus diseases hemic and immune systems Original Articles Middle Aged Viral Load Phenotype 030104 developmental biology HIV-1 Female Immunologic Memory Viral load |
| Popis: | Regulatory T (Treg) cells play a key role in dampening excessive immune activation. However, antiretroviral therapy (ART) -naive HIV-1 infection maintains the immune system in a sustained state of activation that could alter both Treg cell surface markers and functions. As Treg cell surface markers are directly linked to their functions the overall objective of this study was to determine how ART-naive HIV infection affects the phenotypic properties of Treg cells. Our data showed that in ART-naive HIV-1 infection, Treg cells are dominated by effector (CD45RA(+)CD27(-)CCR7(-) CD62L(-)) and effector memory (CD45RA(-)CD27(-)CCR7(-)CD62L(-)) cells. In contrast Treg cells from HIV-negative individuals were mainly naive (CD45RA(+)CD27(+)CCR7(+)CD62L(+)) and central memory (CD45RA(-) CD27(+)CCR7(+)CD62L(+)) cells. Whereas effector and effector memory Treg cells showed enhanced expression of CD39 (P |
| Databáze: | OpenAIRE |
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