Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury
Autor: | Hiroyuki Kojima, Hiroshi Saitoh, Atsuhito Kubota, Fuyo Takeda, Keita Asada, Masako Oda, Masaru Terasaki, Yuichi Ichimura |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Organic Anion Transporters Pharmaceutical Science Ileum urologic and male genital diseases 030226 pharmacology & pharmacy Jejunum 03 medical and health sciences 0302 clinical medicine Internal medicine Intestine Small medicine Animals Pharmacology (medical) Theophylline Pravastatin 030304 developmental biology Pharmacology 0303 health sciences Kidney biology urogenital system Chemistry Acute kidney injury Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Small intestine Rats Organic anion-transporting polypeptide medicine.anatomical_structure Endocrinology biology.protein Cisplatin medicine.drug |
Zdroj: | Drug Metabolism and Pharmacokinetics. 40:100411 |
ISSN: | 1347-4367 |
Popis: | The expression of transporters on the apical and basal membranes of renal tubular cells is modulated under acute kidney injury (AKI). However, little is known about alterations in non-renal transporters in the tissues other than the kidney under AKI situation. This study aimed to assess the modulation of organic anion transporting polypeptide (Oatp) 1a2 and Oatp2b1 expression/function in the small intestine of rats with drug-induced AKI. AKI was induced by intraperitoneal administration of cisplatin at a dose of 5 mg/kg. On day 3 after cisplatin administration, morphological changes in the small intestine, Oatp1a2 and Oatp2b1 expression, and absorption of pravastatin and theophylline were evaluated. Non-negligible atrophy was observed in the jejunum and ileum of the AKI rats. However, the absorption of theophylline was not affected. While intestinal Oatp2b1 expression was markedly decreased in the AKI rats, no alteration was observed in Oatp1a2 expression. The plasma levels of pravastatin after intraluminal administration declined significantly in the AKI rats. However, no such decline was observed after intravenous administration. This study suggested that the responses of intestinal Oatps to experimentally induced AKI was not unidirectional and that pravastatin absorption was governed more potently by Oatp2b1 than by Oatp1a2 in the rat intestine. |
Databáze: | OpenAIRE |
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