Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat
| Autor: | R. J. Chertok, L. B. Sasser, G. E. Jarboe, Michael F. Callaham |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Chronic exposure medicine.medical_specialty Medicine (miscellaneous) chemistry.chemical_element Absorption (skin) In Vitro Techniques Calcium Intestinal absorption Isotopes of calcium Internal medicine medicine Animals Incubation Cadmium Nutrition and Dietetics Dose-Response Relationship Drug Chemistry Radiochemistry Rats Kinetics Endocrinology Intestinal Absorption Concentration gradient |
| Zdroj: | The Journal of Nutrition. 111:631-638 |
| ISSN: | 0022-3166 |
| Popis: | To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 x 10/sup -5/ M Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containing 4 x 10/sup -5/ Ca and Cd in concentrations of 10/sup -4/ to 10/sup -2/ M. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 x 10/sup -4/ M Cd while at 10/sup -6/ M Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium. |
| Databáze: | OpenAIRE |
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