A new class of ultrafine anaphase bridges generated by homologous recombination
| Autor: | Stephen C. West, Ying Wai Chan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genome instability Recombination intermediate chromosomal instability chromosome segregation Review Chromatids Biology Genomic Instability Chromosome segregation 03 medical and health sciences chemistry.chemical_compound Centromere Holliday junction Humans Homologous Recombination Molecular Biology Anaphase MUS81 Cell Biology 53BP1 3. Good health Cell biology 030104 developmental biology chemistry Homologous recombination DNA DNA Damage Developmental Biology |
| Zdroj: | Cell Cycle |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.1080/15384101.2018.1515555 |
| Popis: | Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late replication intermediates induced by replication stress, and DNA linkages at telomeres. Recently, it was reported that DNA intertwinements generated by homologous recombination give rise to a new class of UFBs, which have been termed homologous recombination ultrafine bridges (HR-UFBs). HR-UFBs are decorated with PICH and BLM in anaphase, and are subsequently converted to RPA-coated, single-stranded DNA bridges. Breakage of these sister chromatid entanglements leads to DNA damage that can be repaired by non-homologous end joining in the next cell cycle, but the potential consequences include DNA rearrangements, chromosome translocations and fusions. Visualisation of these HR-UFBs, and knowledge of how they arise, provides a molecular basis to explain how upregulation of homologous recombination or failure to resolve recombination intermediates leads to the development of chromosomal instability observed in certain cancers. |
| Databáze: | OpenAIRE |
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