Gamma-hydroxybutyrate increases brain resting-state functional connectivity of the salience network and dorsal nexus in humans
| Autor: | Oliver G. Bosch, Dario Dornbierer, Robin von Rotz, Michael Kometer, Boris B. Quednow, Michael M. Havranek, Fabrizio Esposito, Philipp Staempfli, Erich Seifritz |
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| Přispěvatelé: | Bosch, O. G., Esposito, F., Dornbierer, D., Havranek, M. M., von Rotz, R., Kometer, M., Staempfli, P., Quednow, B. B., Seifritz, E., University of Zurich, Bosch, Oliver G |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
2805 Cognitive Neuroscience
Adult Male medicine.drug_class Cognitive Neuroscience Sedation Stimulation 610 Medicine & health 050105 experimental psychology 03 medical and health sciences Young Adult 0302 clinical medicine Double-Blind Method Attention network medicine Humans Fronto-parietal network 0501 psychology and cognitive sciences 10064 Neuroscience Center Zurich Intrinsic connectivity Default mode network Brain Mapping Resting state fMRI business.industry Sodium oxybate 05 social sciences Brain Gamma hydroxybutyrate GABA-B Receptor Agonist Magnetic Resonance Imaging Pharmaco-fMRI Dorsomedial prefrontal cortex Neurology Sedative 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics 2808 Neurology GABA-B Receptor Agonists medicine.symptom Nerve Net business Neurocognitive Insula Neuroscience 030217 neurology & neurosurgery Human |
| Popis: | According to the triple network hypothesis the brain is equipped with three core neurocognitive networks: the default mode (DMN), the salience (SN), and the central executive (CEN) network. Moreover, the so called dorsal nexus, has met growing interest as it is a hub region connecting these three networks. Assessment of resting-state functional connectivity (rsFC) of these networks enables the elucidation of drug-induced brain alterations. Gamma-hydroxybutyrate (GHB) is a GHB/GABA-B receptor agonist that induces a paradoxical state of mixed stimulation and sedation at moderate doses, which makes it a valuable tool to investigate neural signatures of subjective drug effects. Employing a placebo-controlled, double-blind, randomized, cross-over design, we assessed the effects of GHB (35 mg/kg p. o.) in 19 healthy male subjects on DMN-, SN-, CEN-, and dorsal nexus-rsFC measured by functional magnet resonance imaging and applying independent component as well as seed-based analyses, while subjective drug effects were investigated using visual analog scales (VAS). Subjectively, GHB increased VAS ratings of a general drug effect, stimulation, and sedation. Intrinsic DMN-, and CEN-rsFC remained largely unchanged under GHB, but the drug increased SN-DMN-rsFC and SN-dorsal nexus-rsFC, while dorsal nexus-rsFC was reciprocally increased to both the SN (right anterior insula) and to the CEN (right middle frontal gyrus). Increased sedation significantly predicted the observed SN-dorsal nexus-rsFC. In conclusion, GHB generates a unique stimulant/sedative subjective state that is paralleled by a complex pattern of increased functional connectivity encompassing all three core neurocognitive networks of the brain, while increased SN-dorsal nexus-rsFC was demonstrated to be a potential signature of the sedative component of the drug effect. |
| Databáze: | OpenAIRE |
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