Malignant Gastrointestinal Stromal Tumor of the Small Intestine Complicated with Pulmonary Tuberculosis during Treatment with Imatinib Mesylate
| Autor: | Fumihiko Tamada, Tomokazu Matsuda, Mototsugu Takashima, Takeo Goto, Minako Ohyama, Naoya Igaki, Suirin Kanda |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Leiomyosarcoma
Male Pathology medicine.medical_specialty Neutropenia Tuberculosis Gastrointestinal Stromal Tumors medicine.drug_class Antitubercular Agents Administration Oral Antineoplastic Agents Gastroenterology Piperazines Tyrosine-kinase inhibitor Fatal Outcome hemic and lymphatic diseases Internal medicine Internal Medicine Humans Medicine Hepatic artery embolization Stromal tumor Tuberculosis Pulmonary neoplasms Digestive System Surgical Procedures Laparotomy Jejunal Neoplasms GiST business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Combined Modality Therapy Malignant Gastrointestinal Stromal Tumor Pyrimidines Imatinib mesylate Benzamides Imatinib Mesylate Tomography X-Ray Computed business |
| Zdroj: | Internal Medicine. 44:114-119 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.44.114 |
| Popis: | We describe a patient who had a metastatic gastrointestinal stromal tumor (GIST) after previous failed extensive therapy, including multiple surgeries and hepatic artery embolization. Within a few months of starting administration of imatinib mesylate, the patient exhibited a clinical response with grade 3 neutropenia, when pulmonary tuberculosis developed. A c-kit mutation in exon 11 was detected only in metastatic liver specimens. It is unclear whether or not pulmonary tuberculosis may be induced by imatinib mesylate treatment, but caution is warranted in immunocompromised GIST patients. This is the first report of tuberculosis associated with neutropenia during imatinib mesylate treatment. |
| Databáze: | OpenAIRE |
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