Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection
| Autor: | Olivier Grosso, Karine Kindbeiter, Stephane Belin, Jean-Xavier Roca-Martinez, Marie Alexandra Albaret, Gabriel Therizols, Jean-Jacques Diaz, Sabine Hacot |
|---|---|
| Přispěvatelé: | Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Idéalp' Pharma, Idealp |
| Rok vydání: | 2009 |
| Předmět: |
MESH: Signal Transduction
MESH: RNA Processing Post-Transcriptional MESH: Enzyme Activation MESH: RNA Polymerase I viruses 5.8S ribosomal RNA MESH: RNA Precursors Ribosome biogenesis MESH: Herpes Simplex Herpesvirus 1 Human MESH: Base Sequence Biology Models Biological Ribosome Article RNA Polymerase I RNA Precursors RNA polymerase I Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology RNA Processing Post-Transcriptional Molecular Biology MESH: Humans Base Sequence MESH: Models Biological RNA Herpes Simplex Ribosomal RNA Molecular biology Cell biology Enzyme Activation MESH: Herpesvirus 1 Human Internal ribosome entry site MESH: HeLa Cells Eukaryotic Ribosome MESH: Ribosomes Ribosomes HeLa Cells Signal Transduction |
| Zdroj: | RNA RNA, Cold Spring Harbor Laboratory Press, 2010, 16 (1), pp.131-40. ⟨10.1261/rna.1935610⟩ |
| ISSN: | 1469-9001 1355-8382 |
| DOI: | 10.1261/rna.1935610 |
| Popis: | The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This process permits control of the ribosome biogenesis rate, giving the possibility of escaping ribosomal stress and eventually allowing assembly of specialized kinds of ribosomes. |
| Databáze: | OpenAIRE |
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