Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen
Autor: | Ryo Yamakuni, Ayaka Nemoto, Shiro Ishii, Hitoshi Kubo, Kazuhiro Takahashi, Masanobu Ibaraki, Shigeyasu Sugawara, Ken-ichi Nishijima, Naoyuki Ukon, Hiroshi Ito |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Scanner Cerebral metabolic rate chemistry.chemical_element Oxygen 030218 nuclear medicine & medical imaging 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Oxygen Radioisotopes Cerebral Blood Volume Humans Medicine Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Cerebral Cortex business.industry General Medicine Magnetic Resonance Imaging Cerebrovascular Disorders Cerebral blood volume Cerebral blood flow chemistry Cerebrovascular Circulation Positron-Emission Tomography 030220 oncology & carcinogenesis Metabolome Gases Cerebral oxygen business Nuclear medicine Correction for attenuation circulatory and respiratory physiology |
Zdroj: | Annals of Nuclear Medicine. 35:421-428 |
ISSN: | 1864-6433 0914-7187 |
Popis: | Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) by PET with oxygen-15 labeled gases is useful for diagnosis and treatment planning in cases of chronic occlusive cerebrovascular disease. In the present study, CBF, CBV, OEF and CMRO2 were measured using the integrated design of PET/MRI scanner system. This is a first attempt to measure cerebral perfusion and oxygen metabolism using PET/MRI with oxygen-15 labeled gases. PET/MRI measurements with the steady-state method of oxygen-15 labeled gases, carbon monoxide (C15O), oxygen (15O2), and carbon dioxide (C15O2) were performed on nine healthy men. Two kinds of attenuation correction for PET were performed using MRI with Dixon sequence (DIXON) and Dixon sequence with model-based bone segmentation (DIXONbone). A real-time motion correction of PET images was also performed using simultaneously measured MR images to detect head motion. Mean and SD values of CBF, CBV, OEF, and CMRO2 in the cerebral cortices with attenuation correction by DIXON were 31 ± 4 mL/100 mL/min, 2.7 ± 0.2 mL/mL, 0.40 ± 0.07, and 2.5 ± 0.3 mL/100 mL/min without real-time motion correction, and 33 ± 4 mL/100 mL/min, 2.7 ± 0.2 mL/mL, 0.40 ± 0.07, and 2.6 ± 0.3 mL/100 mL/min with real-time motion correction, respectively. Values with of CBF, CBV, OEF, and CMRO2 with attenuation correction by DIXONbone were 35 ± 5 mL/100 mL/min, 2.8 ± 0.2 mL/mL, 0.40 ± 0.07, and 2.8 ± 0.3 mL/100 mL/min without real-time motion correction, and 38 ± 5 mL/100 mL/min, 2.8 ± 0.2 mL/mL, 0.40 ± 0.07, and 3.0 ± 0.4 mL/100 mL/min with real-time motion correction, respectively. Using PET/MRI with oxygen-15 labeled gases, CBF, CBV, OEF, and CMRO2 could be measured. Values of CBF, CBV, and CMRO2 measured with attenuation correction by DIXON were significantly lower than those measured with correction by DIXONbone. One of the reasons for this is that attenuation correction of DIXON does not take into consideration of the photon absorption by bone. OEF values, corresponding to ratios of CMRO2 to CBF, were not affected by attenuation correction methods. Values of CBF and CMRO2 with a real-time motion correction were significantly higher than those without correction. Using PET/MRI with adequate corrections, similar values of CBF, CBV, OEF, and CMRO2 as PET alone scanner system reported previously were obtained. The UMIN clinical trial number: UMIN000033382. |
Databáze: | OpenAIRE |
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