Aqueous extracts of cigarette smoke promote the oxidation of low density lipoprotein by peroxidases
| Autor: | Sheldon S. Hendler, Sampath Parthasarathy, Robert A. Sanchez, Nalini Santanam |
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| Rok vydání: | 1997 |
| Předmět: |
Biophysics
Pharmacology Biochemistry Horseradish peroxidase Lipid peroxidation Oxidized low density lipoprotein chemistry.chemical_compound Structural Biology In vivo Smoke parasitic diseases Genetics Humans Hydrogen peroxide Molecular Biology Peroxidase Aqueous solution Dose-Response Relationship Drug biology Smoking Cell Biology Atherosclerosis Cardiovascular disease Oxidants Lipoproteins LDL Peroxidases chemistry Low-density lipoprotein Myeloperoxidase biology.protein lipids (amino acids peptides and proteins) Lipid Peroxidation Copper |
| Zdroj: | FEBS Letters. 414:549-551 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(97)01067-3 |
| Popis: | Oxidation of low density lipoprotein (LDL) by cigarette smoke has been considered a potential mechanism by which smoking may promote atherosclerosis. We report in this study that cigarette smoke extract (CSE) inhibited copper-induced oxidation of LDL suggesting the presence of antioxidants in CSE. It is currently believed that peroxidases may oxidize LDL in vivo and during such oxidations antioxidants become pro-oxidants. Accordingly, when LDL was oxidized by peroxidase in the presence of CSE there was an increase in the oxidation of LDL. This is the first study suggesting that smoking may promote atherosclerosis by enhancing peroxidase-catalyzed lipid peroxidation. |
| Databáze: | OpenAIRE |
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