Prevalence and Prognostic Significance of Wall-Motion Abnormalities in Adults Without Clinically Recognized Cardiovascular Disease
| Autor: | Thomas K. Welty, Barbara V. Howard, Mary J. Roman, Giovanni de Simone, Wenyu Wang, James M. Galloway, Lyle G. Best, Richard B. Devereux, Elisa T. Lee, S. Cicala |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Heart Ventricles Myocardial Infarction MEDLINE Disease Angina Pectoris Cohort Studies Risk Factors Physiology (medical) Internal medicine Prevalence Ventricular Dysfunction medicine Humans In patient Wall motion Aged Left ventricular wall motion business.industry Follow up studies Middle Aged Prognosis medicine.disease United States Cardiovascular Diseases Echocardiography Indians North American Cardiology Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Circulation. 116:143-150 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.106.652149 |
| Popis: | Background— Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocardiographic WM abnormalities predict subsequent cardiovascular events in a population-based sample. Methods and Results— Participants (n=2864, mean age 60±8 years, 64% women) without clinically evident cardiovascular disease in the second Strong Heart Study examination who had complete echocardiographic WM assessment were studied. Echocardiographic assessment revealed that 5% of participants (n=140) had focal hypokinesia, and 1.5% (n=42) had WM abnormalities. Relationships between WM abnormalities and fatal and nonfatal cardiovascular events (including myocardial infarction, stroke, coronary artery disease, and heart failure; n=554) and cardiovascular death (n=182) during 8±2 years follow-up were examined. In Cox regression, after adjustment for age, gender, waist/hip ratio, systolic blood pressure, and diabetes mellitus, segmental WM abnormalities were associated with a 2.5-fold higher risk of cardiovascular events and a 2.6-fold higher risk of cardiovascular death (both P P =0.001) and a 3.4-fold higher risk of cardiovascular death ( P =0.003). Conclusions— Echocardiographic left ventricular WM abnormalities in adults without overt cardiovascular disease are associated with 2.4- to 3.4-fold higher risks of cardiovascular morbidity and mortality, independent of established risk factors. |
| Databáze: | OpenAIRE |
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