Histopathological, Radiological, and Demographic Factors Predicting the Response to Neoadjuvant Therapy for Rectal Cancer
| Autor: | Zekeriya Pelen, Emine Yildirim, Irem Yanik, Sibel Bektas, Perihan Özkan Gümüşkaya, Ahmet Muzaffer Er, Ferhat Cengel |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer Lymphovascular invasion business.industry Rectal Neoplasms medicine.medical_treatment Gastroenterology Perineural invasion Chemoradiotherapy medicine.disease Neoadjuvant Therapy Radiation therapy Treatment Outcome Oncology medicine Anal verge Humans Radiology Stage (cooking) business Neoadjuvant therapy Demography Retrospective Studies |
| Zdroj: | Journal of gastrointestinal cancerReferencess. 53(1) |
| ISSN: | 1941-6636 |
| Popis: | Background/aimWhile the treatment for early stage rectal cancer is surgery, when a diagnosis is made at a locally advanced stage, it is recommended to start treatment with neoadjuvant chemoradiotherapy. Therefore, it is important to determine which patients will respond best to neoadjuvant treatment. The aim of this study was to investigate which hematological, histopathological, and radiological parameters can predict the response to chemoradiotherapy. Methods and materialsA retrospective examination was made of 43 patients who underwent surgery following neoadjuvant chemoradiotherapy because of locally advanced stage rectal cancer. Demographic data were collected from the patient files, and the radiological, histopathological and laboratory findings before neoadjuvant chemoradiotherapy were compared with the findings after treatment. ResultsIn the postoperative evaluation, a pathological complete response was determined in 25.50% of the patients. Lymphovascular invasion, perineural invasion and absence of necrosisis were seen to be statistically related to major response (p, and in patients where the tumor was closer than 6cm to the anal verge, the response was betterConclusionWhen the findings were examined, histopathological lymphovascular invasion, perineural invasion, the presence of necrosis, and the anal verge distance were evaluated as parameters predicting the response to neoadjuvant chemoradiotherapy in rectal cancer. |
| Databáze: | OpenAIRE |
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