The intestinal microenvironment in sepsis
| Autor: | Craig M. Coopersmith, Mandy L. Ford, Katherine T. Fay |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Multiple Organ Failure Biology Article Sepsis 03 medical and health sciences Basal (phylogenetics) Immune system medicine Animals Humans Lymphocytes Microbiome Intestinal Mucosa Molecular Biology Gastrointestinal tract medicine.disease Epithelium Gastrointestinal Microbiome 030104 developmental biology medicine.anatomical_structure Immunology Molecular Medicine Multiple organ dysfunction syndrome Homeostasis |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2574-2583 |
| ISSN: | 0925-4439 |
| Popis: | The gastrointestinal tract has long been hypothesized to function as “the motor” of multiple organ dysfunction syndrome. The gastrointestinal microenvironment is comprised of a single cell layer epithelia, a local immune system, and the microbiome. These three components of the intestine together play a crucial role in maintaining homeostasis during times of health. However, the gastrointestinal microenvironment is perturbed during sepsis, resulting in pathologic changes that drive both local and distant injury. In this review, we seek to characterize the relationship between the epithelium, gastrointestinal lymphocytes, and commensal bacteria during basal and pathologic conditions and how the intestinal microenvironment may be targeted for therapeutic gain in septic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect