Specific antibodies induced by nasally administered 40-kDa outer membrane protein of Porphyromonas gingivalis inhibits coaggregation activity of P. gingivalis
| Autor: | Shigeo Otake, Masafumi Yamamoto, Satomi Maeba, Mitsuo Hayakawa, Jun Namikoshi, Yoshimitsu Abiko |
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| Rok vydání: | 2003 |
| Předmět: |
Saliva
chemical and pharmacologic phenomena medicine.disease_cause complex mixtures Immunoglobulin G Bacterial Adhesion Microbiology Mice Adjuvants Immunologic medicine Animals Porphyromonas gingivalis Administration Intranasal Antigens Bacterial Mice Inbred BALB C General Veterinary General Immunology and Microbiology biology Cholera toxin Public Health Environmental and Occupational Health Antibody titer respiratory system bacterial infections and mycoses biology.organism_classification Antibodies Bacterial Infectious Diseases Immunology Humoral immunity biology.protein bacteria Molecular Medicine Immunization Antibody Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Vaccine. 22(2) |
| ISSN: | 0264-410X |
| Popis: | In this study, we have assessed the efficacy of the 40-kDa outer membrane protein (40k-OMP) of Porphyromonas gingivalis as a nasal vaccine for the prevention of adult periodontitis. Mice nasally immunized with 40k-OMP and cholera toxin as mucosal adjuvant displayed significant levels of 40k-OMP-specific serum IgG1, IgG2b and IgA as well as mucosal IgA antibodies (Abs) in saliva and nasal secretions. Ab-forming cell (AFC) analysis confirmed the antibody titers by detecting high numbers of 40k-OMP-specific AFCs in spleen, salivary glands and nasal passages. Because 40k-OMP-specific IgG inhibited coaggregation of P. gingivalis vesicles and S. gordonii, it may be an important tool for the prevention of adult periodontitis. |
| Databáze: | OpenAIRE |
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