Effectiveness of Commonly Used Contact Lens Disinfectants Against SARS-CoV-2

Autor: Veugen, Judith M J, Nuijts, Rudy M M A, van den Biggelaar, Frank J H M, Gijs, Marlies, Savelkoul, Paul H M, Wolffs, Petra F G, Dickman, Mor M
Přispěvatelé: Medical Microbiology and Infection Prevention, AII - Infectious diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Oogheelkunde, RS: MHeNs - R3 - Neuroscience, MUMC+: AB Refractie Chirurgie Oogheelkunde (9), MUMC+: MA Oogheelkunde (9), Medische Microbiologie, MUMC+: DA Medische Microbiologie en Infectieziekten (5), RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R4 - Health Inequities and Societal Participation, MUMC+: DA MMI Staf (9)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Eye & contact lens, 48(9), 362-368. Lippincott Williams and Wilkins Ltd.
Veugen, J M J, Nuijts, R M M A, van den Biggelaar, F J H M, Gijs, M, Savelkoul, P H M, Wolffs, P F G & Dickman, M M 2022, ' Effectiveness of Commonly Used Contact Lens Disinfectants Against SARS-CoV-2 ', Eye & contact lens, vol. 48, no. 9, pp. 362-368 . https://doi.org/10.1097/ICL.0000000000000925
Eye & Contact Lens-Science and Clinical Practice, 48(9), 362-368. LIPPINCOTT WILLIAMS & WILKINS
ISSN: 1542-233X
1542-2321
DOI: 10.1097/ICL.0000000000000925
Popis: OBJECTIVE: To assess the effect of commonly used contact lens disinfectants against severe acute respiratory syndrome corona virus 2 (SARS-CoV-2).METHODS: The efficacy of five disinfectant solutions against SARS-CoV-2 was tested in the presence and absence of contact lenses (CLs). Three types of unused CLs (hard gas permeable, soft hydrogel, and soft silicone hydrogel) and worn silicone hydrogel CLs were tested. Contact lenses were infected with SARS-CoV-2 and disinfected at various times, with and without rubbing and rinsing, as per manufacturer's instructions. Reverse-transcriptase polymerase chain reaction (RT-PCR) and viability polymerase chain reaction (PCR) were applied to detect SARS-CoV-2 RNA and viral infectivity of SARS-CoV-2, respectively.RESULTS: In the presence of SARS-CoV-2-infected CLs, no SARS-CoV-2 RNA could be detected when disinfectant solutions were used according to the manufacturer's instructions. When SARS-Co-V2-infected CLs were disinfected without the rub-and-rinse step, SARS-CoV-2 RNA was detected at almost each time interval with each disinfecting solution tested for both new and worn CLs. In the absence of CLs, viable SARS-CoV-2 was detected with all disinfectant solutions except Menicon Progent at all time points.CONCLUSIONS: Disinfectant solutions effectively disinfect CLs from SARS-CoV-2 if manufacturer's instructions are followed. The rub-and-rinse regimen is mainly responsible for disinfection. The viability PCR may be useful to indicate potential infectiousness.
Databáze: OpenAIRE
Externí odkaz: