Ethical issues in stem cell research and therapy
| Autor: | Nancy M. P. King, Jacob Perrin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Clinical Trials as Topic
Therapeutic misconception business.industry Mesenchymal stem cell Cell Culture Techniques Cell- and Tissue-Based Therapy Medicine (miscellaneous) Translational research Cell Biology Review Stem Cell Research Biochemistry Genetics and Molecular Biology (miscellaneous) Embryonic stem cell Biotechnology Multipotent Stem Cell Molecular Medicine Medicine Humans Engineering ethics Justice (ethics) Stem cell business Induced pluripotent stem cell Embryonic Stem Cells Stem Cell Transplantation |
| Zdroj: | Stem Cell Research & Therapy |
| ISSN: | 1757-6512 |
| Popis: | Rapid progress in biotechnology has introduced a host of pressing ethical and policy issues pertaining to stem cell research. In this review, we provide an overview of the most significant issues with which the stem cell research community should be familiar. We draw on a sample of the bioethics and scientific literatures to address issues that are specific to stem cell research and therapy, as well as issues that are important for stem cell research and therapy but also for translational research in related fields, and issues that apply to all clinical research and therapy. Although debate about the moral status of the embryo in human embryonic stem cell research continues to have relevance, the discovery of other highly multipotent stem cell types and alternative methods of isolating and creating highly multipotent stem cells has raised new questions and concerns. Induced pluripotent stem cells hold great promise, but care is needed to ensure their safety in translational clinical trials, despite the temptation to move quickly from bench to bedside. A variety of highly multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from amniotic fluid, umbilical cord blood, adipose tissue, or urine - present the opportunity for widespread biobanking and increased access. With these increased opportunities, however, come pressing policy issues of consent, control, and justice. The imperatives to minimize risks of harm, obtain informed consent, reduce the likelihood of the therapeutic misconception, and facilitate sound translation from bench to bedside are not unique to stem cell research; their application to stem cell research and therapy nonetheless merits particular attention. Because stem cell research is both scientifically promising and ethically challenging, both the application of existing ethical frameworks and careful consideration of new ethical implications are necessary as this broad and diverse field moves forward. |
| Databáze: | OpenAIRE |
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