Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
| Autor: | Tarek A. Samad, David P. Corey, Jaime García-Añoveros, Zuvela-Jelaska L, Clifford J. Woolf |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Male
Patch-Clamp Techniques Molecular Sequence Data Nerve Tissue Proteins CHO Cells Transfection Ion Channels Sodium Channels Degenerin Sodium Channels Rats Sprague-Dawley Mice Dorsal root ganglion Cricetinae Ganglia Spinal medicine Animals Protein Isoforms Patch clamp Neurons Afferent Mechanotransduction ARTICLE Cloning Molecular Epithelial Sodium Channels Acid-sensing ion channel Skin Chemistry General Neuroscience Sodium channel Physical Chromosome Mapping Rats Acid Sensing Ion Channels Protein Transport medicine.anatomical_structure nervous system Organ Specificity Nociceptor Neuroscience Transduction (physiology) Mechanoreceptors |
| Popis: | Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the BNaC1α isoform is expressed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception) and few small nociceptor neurons (which include high-threshold mechanoreceptors). BNaC1α is transported from DRG cell bodies to sensory terminals in the periphery, but not to the spinal cord, and is located specifically at specialized cutaneous mechanosensory terminals, including Meissner, Merkel, penicillate, reticular, lanceolate, and hair follicle palisades as well as some intraepidermal and free myelinated nerve endings. Accordingly, BNaC1α channels might participate in the transduction of touch and painful mechanical stimuli. |
| Databáze: | OpenAIRE |
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