An innovative small molecule for promoting neuroreparative strategies
| Autor: | Francesco Berardi, Annamaria Tonazzi, Lara Console, Gert Luurtsema, Nicola Antonio Colabufo, Roberto Perrone, Marialessandra Contino, Mariangela Cantore, Heli Savolainen, Maria Antonietta Panaro |
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| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
EXPRESSION Neurite sprouting DERIVATIVES neurite sprouting General Chemical Engineering Cellular differentiation Neurodegeneration Tlr4 signaling General Chemistry Biology medicine.disease Small molecule Cell biology 03 medical and health sciences MICE 030104 developmental biology Immunocytochemistry In vivo CELLS TLR4 medicine BRAIN neuroregeneration |
| Zdroj: | RSC advances 8 (2018): 5451–5458. doi:10.1039/c7ra11812k info:cnr-pdr/source/autori:Nicola Antonio Colabufo, Marialessandra Contino, Mariangela Cantore, Francesco Berardi, Roberto Perrone, Annamaria Tonazzi, Lara Console, Maria Antonietta Panaro, Heli Savolainenf and Gert Luurtsema/titolo:An innovative small molecule for promoting neuroreparative strategies/doi:10.1039%2Fc7ra11812k/rivista:RSC advances/anno:2018/pagina_da:5451/pagina_a:5458/intervallo_pagine:5451–5458/volume:8 RSC Advances, 8(10), 5451-5458. ROYAL SOC CHEMISTRY |
| ISSN: | 2046-2069 |
| Popis: | In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of MC111, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by MC111, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the in vivo evaluation of MC111 as new tool in neuroreparative medicine. |
| Databáze: | OpenAIRE |
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