Occurrence of kidney diseases and patterns of glomerular disease based on a 10-year kidney biopsy material: a retrospective single-centre analysis in Estonia

Autor:	Mai Ots-Rosenberg, Zivile Riispere
Rok vydání:	2012
Předmět:	Adult Estonia Male medicine.medical_specialty Pathology Adolescent Glomerulonephritis Membranoproliferative Urology Nephrosis Biopsy Glomerulonephritis Sex Factors Internal medicine Epidemiology medicine Humans Child Aged Retrospective Studies Aged 80 and over Kidney medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental Nephrosis Lipoid Glomerulosclerosis Retrospective cohort study Glomerulonephritis IGA Middle Aged medicine.disease medicine.anatomical_structure Nephrology Child Preschool Nephritis Interstitial Female Kidney Diseases business Tubulointerstitial Disease
Zdroj:	Scandinavian journal of urology and nephrology. 46(5)
ISSN:	1651-2065
Popis:	Kidney biopsy is an important diagnostic tool in assessing glomerular damage. This study aimed to determine the occurrence of glomerular disease during the past decade at a single centre, to assess potential changes in the structure of primary glomerulopathies over time, and to define gender- and age-related differences.A total of 578 consecutive native kidney biopsies during the period 2000-2010 was retrospectively reviewed at Tartu University Hospital, Estonia. Biopsies were evaluated according to clinical data with standard histological methods.The patients' mean age was 39.9 ± 17.9 (range 4-87) years. Less than half of informative kidney biopsies (n = 547) comprised primary glomerulopathies (45.4%), the patients' mean age was 38.7 ± 17.7 (4-79) years and the predominant group comprised male patients. Secondary glomerulopathies made up 22.3%, tubulointerstitial diseases 8.2% and other conditions 24.1%. Among primary glomerulopathies, inflammatory damage to glomeruli dominated (63.4%), whereas immunoglobulin A (IgA) nephropathy was the most common disease (35.5%). Non-inflammatory diseases of glomeruli made up 34.6%, among which the most common was focal and segmental glomerulosclerosis (16.1%), followed by minimal change disease (14.1%). Membranoproliferative glomerulonephritis was a rare form of glomerular damage among primary glomerulopathies (7.7%). Comparison between male and female cases in the primary glomerulopathies group revealed a statistically significant difference in their frequency (p = 0.01).Inflammatory glomerulopathies mostly prevailed in the spectrum of primary glomerulopathies. IgA nephropathy was the most common glomerulopathy. Comparing the data with those from a 15-year earlier period at the same centre, a change towards non-inflammatory glomerulopathies was noticed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d65e0611f7881bc284b74e1d89f924b https://pubmed.ncbi.nlm.nih.gov/22725262 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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