PinX1: structure, regulation and its functions in cancer
| Autor: | Hailong Li, Jin Bai, Wen-Bo Song, Junnian Zheng, Pingfu Hou, Yan-Su Chen, Hongmei Yong, Jun Song |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Telomerase Cell Cycle Proteins Review Malignancy 03 medical and health sciences Neoplasms Humans cancer Medicine structure PINX1 Gene function PinX1 Mechanism (biology) business.industry Tumor Suppressor Proteins Cancer regulation medicine.disease Telomere Gene Expression Regulation Neoplastic 030104 developmental biology Oncology Cancer research business Function (biology) |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.11411 |
| Popis: | PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene located at human chromosome 8p23, playing a vital role in maintaining telomeres length and chromosome stability. It has been demonstrated to be involved in tumor genesis and progression in most malignancies. However, some researches showed opposing molecular status of PinX1 gene and its expression patterns in several other types of tumors. The pathogenic mechanism of PinX1 expression in human malignancy is not yet clear. Moreover, emerging evidence suggest that PinX1 (especially its TID domain) might be a potential new target cancer treatment. Therefore, PinX1 may be a new potential diagnostic biomarker and therapeutic target for human cancers, and may play different roles in different human cancers. The functions and the mechanisms of PinX1 in various human cancers remain unclear, suggesting the necessity of further extensive works of its role in tumor genesis and progression. |
| Databáze: | OpenAIRE |
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