DNA methylation in adolescents with anxiety disorder: a longitudinal study
| Autor: | Giovanni Abrahão Salum, Vinicius S Chagas, Andressa Bortoluzzi, Gisele Gus Manfro, Eduarda Dias da Rosa, Mauro A. A. Castro |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Longitudinal study Adolescent lcsh:Medicine Estudos longitudinais Anxiety Metilação de DNA Article Epigenesis Genetic Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Longitudinal Studies Epigenetics Young adult lcsh:Science Child Adolescente Multidisciplinary business.industry lcsh:R DNA Methylation medicine.disease Anxiety Disorders Transtornos de ansiedade 030104 developmental biology Cohort DNA methylation lcsh:Q CpG Islands Female medicine.symptom business 030217 neurology & neurosurgery Anxiety disorder Cohort study |
| Zdroj: | Scientific Reports Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Anxiety disorders (AD) typically manifest in children and adolescents and might persist into adulthood. However, there are still few data concerning epigenetic mechanisms associated with onset, persistence or remission of AD over time. We investigated a cohort of adolescents and young adults at baseline (age; 13.19 ± 2.38) and after 5 years and classified them according to the AD diagnosis and their longitudinal trajectories into 4 groups: (1) Typically Developing Comparisons (TDC; control group, n = 14); (2) Incident (AD in the second evaluation only, n = 11); (3) Persistent (AD in both evaluations, n = 14) and (4) Remittent (AD in the first evaluation only, n = 8). DNA methylation was evaluated with the Infinium HumanMethylation450 BeadChip from saliva samples collected at both evaluations. Gene set enrichment analysis was applied to consider biological pathways. We found decreased DNA methylation in TDC group while the chronic cases of AD presented hypermethylation in central nervous system development pathways. Moreover, we showed that this persistent group also presented hypermethylation while the other three groups were associated with hypomethylation in nervous system development pathway. Incidence and remission groups were associated with increased and decreased methylation in neuron development pathways, respectively. Larger studies are likely to detect specific genes relevant to AD. |
| Databáze: | OpenAIRE |
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