Dopamine receptor turnover rates in rat striatum are age-dependent
| Autor: | R. Gariano, I. Crease, S. E. Leff |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Senescence Aging medicine.medical_specialty Reserpine Irreversible antagonist Age dependent Striatum Biology Cycloheximide Receptors Dopamine Rat striatum chemistry.chemical_compound Dopamine receptor D1 Downregulation and upregulation Internal medicine medicine Animals Pharmacology (medical) Receptor Pharmacology Multidisciplinary Corpus Striatum Rats Kinetics Endocrinology chemistry Dopamine receptor Quinolines Neurology (clinical) Research Article medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 81:3910-3914 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.81.12.3910 |
| Popis: | The time course of recovery of [3H]spiperone binding in the rat striatum after a single injection of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) shows that a slower rate of regeneration/turnover of D-2 dopamine receptors occurs in mid-life-mature versus young male rats. This slower receptor recovery reflects relatively slower rates of both receptor synthesis and degradation. Studies using cycloheximide indicate that protein synthesis plays a significant role in the reappearance of [3H]spiperone-binding sites. Other experiments indicate that chronic reserpine treatment, which produces dopamine receptor up regulation, also produces accelerated receptor recovery after EEDQ blockade. An age-related decline in dopamine receptor turnover, if present in humans and progressive into senescence, could be responsible for the increased risk of developing Parkinson disease and drug-induced parkinsonian-like extrapyramidal side effects with age. On the other hand, the more rapid receptor turnover rates seen in young rats may be a biochemical feature related to plasticity in the striatum during development. |
| Databáze: | OpenAIRE |
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