Exosome mediated differentiation of megakaryocytes: a study on TLR mediated effects
| Autor: | Ravi Kumar Gutti, Sanjeev Raghuwanshi, Narasaiah Kovuru |
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| Rok vydání: | 2019 |
| Předmět: |
030204 cardiovascular system & hematology
Exosomes Exosome 03 medical and health sciences 0302 clinical medicine Megakaryocyte Medicine Humans Platelet 030212 general & internal medicine Receptor Progenitor Innate immune system business.industry Toll-Like Receptors Cell Differentiation Hematology Thrombocytopenia Microvesicles Immunity Innate Toll-Like Receptor 2 Cell biology medicine.anatomical_structure Bone marrow Cardiology and Cardiovascular Medicine business Megakaryocytes |
| Zdroj: | Journal of thrombosis and thrombolysis. 48(1) |
| ISSN: | 1573-742X |
| Popis: | Megakaryocytes are large polyploid bone marrow cells whose function is to produce circulatory platelets. Megakaryocytes are also known to release extracellular vesicles (EVs) of varying sizes. Toll like receptors (TLRs), present on the sentinel cells are essential components of the innate immune response, these receptors are also expressed by platelets and megakaryocytes. Our data provide the evidence that TLR-2 induced MKEVs are able to recapitulate TLR-2 signalling in megakaryocytic cell line (Dami cells) and that likely induces megakaryocytic maturation by increasing the production of cytokines involved in MK maturation. TLR-2 induced MKEVs may be involved in replenishment of the immune effector platelets in circulation and its progenitor megakaryocyte in bone marrow for the physiological need of the platelets by inducing the maturation of megakaryocyte. |
| Databáze: | OpenAIRE |
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