The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines

Autor:	J.S. Skotnicki, Zhang-Bao Xu, T. Wehr, Mila T. Du, Roy A. Black, C. E. Roth, Li Di, James M. Chen, Jeremy I. Levin, Michele A. Sharr, C.J March, R. Cowling, John F. DiJoseph, S. Skala, Kendall M. Mohler, Amy Sung, Mary M. Sherman, Frances C. Nelson, Loran M. Killar, G. Jin
Rok vydání:	2001
Předmět:	Models Molecular Magnetic Resonance Spectroscopy Stereochemistry Clinical Biochemistry Interleukin-1beta Pharmaceutical Science ADAM17 Protein Matrix Metalloproteinase Inhibitors Hydroxamic Acids Biochemistry Chemical synthesis chemistry.chemical_compound Mice Structure-Activity Relationship In vivo Drug Discovery Matrix Metalloproteinase 13 Osteoarthritis Anthranilic acid Animals ortho-Aminobenzoates Collagenases Amines Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Hydroxamic acid Binding Sites biology Organic Chemistry Metalloendopeptidases Sulfonamide Rats Piperazine ADAM Proteins Enzyme chemistry Matrix Metalloproteinase 9 Enzyme inhibitor biology.protein Molecular Medicine Matrix Metalloproteinase 1 Interleukin-1
Zdroj:	Bioorganicmedicinal chemistry letters. 11(22)
ISSN:	0960-894X
Popis:	Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5e19bf3f666ee2e11c3aa0f30e660c https://pubmed.ncbi.nlm.nih.gov/11677139 Zobrazit plný text záznamu Full Text from ScienceDirect