The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices
| Autor: | Mohammad Shabani, Nasser Zangiabadi, Majid Asadi-Shekaari, Mahboobeh Hojatipour, Mandana Jafari, Hossein Mohtashami |
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| Rok vydání: | 2014 |
| Předmět: |
Diabetic neuropathy
Article Subject medicine.medical_treatment Intraperitoneal injection Neural Conduction lcsh:Medicine lcsh:Technology Streptozocin General Biochemistry Genetics and Molecular Biology Nerve conduction velocity Diabetes Mellitus Experimental Diabetic Neuropathies Diabetes mellitus Peripheral Nervous System Animals Humans Medicine Umbelliferones lcsh:Science General Environmental Science Flavonoids Motor Neurons Melilotus Behavior Animal lcsh:T Plant Extracts business.industry lcsh:R General Medicine medicine.disease Streptozotocin Sciatic Nerve Rats Electrophysiology medicine.anatomical_structure Anesthesia Peripheral nervous system lcsh:Q Sciatic nerve business Research Article medicine.drug |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2014 (2014) |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats. |
| Databáze: | OpenAIRE |
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