Einfluss von niedrig-dosiertem Dopexamin auf die Gewebeperfusion im Magenschlauch des Schweines
| Autor: | D. Stähler, C. Gutschow, J.H. Fischer, K. T. E. Beckurts, Arnulf H. Hölscher, Wolfgang Schröder |
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| Jazyk: | němčina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | 121. Kongress der Deutschen Gesellschaft für Chirurgie; 20040427-20040430; Berlin; DOC04dgch0142 /20041007/ Deutsche Gesellschaft für Chirurgie ISBN: 9783540200277 |
| Popis: | This experimental setting investigates the influence of dopexamine-hydrochloride (DOPACARD®, Medeus Pharma GmbH, Deutschland) on tissue perfusion of the gastric tube. After laparotomy and formation of a gastric tube in 13 pigs dopexamine was continuously administered in increasing concentrations of 0.5,1.0 and 2.0 µg/kg KG/min over 45 minutes each. Before (To) and during application (T1 20 min; T2 40 min) tissue perfusion was measured in the fundus, corpus and antrum using a laser-doppler imager (in perfusion units, PU). 0.5 ug dopexamine/kg KG/min induced a significant increase of tissue perfusion in the gastric fundus (To: 226 PU± 118; T1: 319 PU ± 166; p = 0.004). 1.0 jug dopexamine/kg KG/min significantly increased tissue perfusion of the entire gastric tube (To: 509 PU ± 177; T1: 570 PU ± 190, p = 0.035; T2: 614 PU ± 159, p = 0.003). This effect was not observed for 2.0 µg dopexamine/kg KG/min. |
| Databáze: | OpenAIRE |
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