Risk of bipolar disorder in patients with polycystic ovary syndrome: A nationwide population-based cohort study
| Autor: | Chung Y. Hsu, Shih Fen Chen, Yu Cih Yang, Yu Chih Shen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Bipolar Disorder endocrine system diseases medicine.medical_treatment Clomiphene Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Bipolar disorder business.industry Proportional hazards model Hazard ratio nutritional and metabolic diseases medicine.disease Polycystic ovary Metformin Confidence interval 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cohort Female Hormone therapy business 030217 neurology & neurosurgery Polycystic Ovary Syndrome medicine.drug |
| Zdroj: | Journal of Affective Disorders. 263:458-462 |
| ISSN: | 0165-0327 |
| Popis: | Background The study investigated the risk of newly developed bipolar disorder (BD) in patients with polycystic ovary syndrome (PCOS) and examined the relationship between PCOS treatment (hormone therapy (clomiphene or cyproterone) or metformin) and risk of BD development. Methods In all, 7175 PCOS patients and 28,697 non-PCOS controls matched by age, index year, and Charlson Comorbidity Index (CCI) score were included between 2000 and 2012, then followed until the end of 2013. Participants newly diagnosed as BD by board-certified psychiatrists were defined as incidents. Cox regression analysis was used to calculate the hazard ratio (HR) with 95% confidence interval (CI) of the BD incidence rate between two studied groups. Results PCOS patients had a significantly increased risk of developing BD compared to unaffected controls after adjusting for age, CCI score, and different treatment options (1.05 vs. 0.12 per 1,000 person-years, HR: 8.29, 95% CI: 4.65–14.7). Also, the use of metformin in PCOS patients showed a significantly reduced risk of developing BD compared to non-users after adjusting for the above-mentioned variables (HR: 0.36, 95% CI: 0.16–0.81). Although hormone therapy in PCOS patients showed a lower incidence rate of BD development compared to non-users, the risk estimate was not statistically significant (HR: 0.68, 95% CI: 0.35–1.32). Limitations This study didn't assess the PCOS severity, which reduced the chances of showing the effects of PCOS severity on BD development. Conclusion This study shows PCOS patients have an increased risk of developing BD, and the use of metformin may reduce its risk. |
| Databáze: | OpenAIRE |
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