A three-dimensional morphometric study of craniofacial shape in schizophrenia

Autor: Michael Yerukhimovich, David Dean, Peter F. Buckley, Kyoung June Min, Beth Singer, Fred L. Bookstein, Seungho Han
Rok vydání: 2005
Předmět:
Zdroj: The American journal of psychiatry. 162(3)
ISSN: 0002-953X
Popis: Background: Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. METHOD: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. RESULTS: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. CONCLUSIONS: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
Databáze: OpenAIRE