Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
| Autor: | Fei Liu, Lukas Wanka, Inge Grundke-Iqbal, Muhammad Omar Chohan, Julie Blanchard, Khalid Iqbal, Bin Li |
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| Rok vydání: | 2010 |
| Předmět: |
Aging
Ciliary neurotrophic factor Neurogenesis Biophysics Synaptogenesis Adamantane Biology Leukemia Inhibitory Factor Biochemistry Subgranular zone Mice Cognition Memory Structural Biology Neuroplasticity Genetics medicine Animals Adamantane derivative Nerve Growth Factors Molecular Biology Pharmacology Behavior Animal Dentate gyrus Recognition Psychology Cell Biology medicine.anatomical_structure nervous system Neuronal plasticity Dentate Gyrus Synapses Immunology Synaptic plasticity biology.protein Alzheimer disease Oligopeptides Neuroscience Signal Transduction Neurotrophin |
| Zdroj: | FEBS Letters. 584:3359-3365 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2010.06.025 |
| Popis: | Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus. |
| Databáze: | OpenAIRE |
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