Titanium and steel fracture fixation plates with different surface topographies: Influence on infection rate in a rabbit fracture model
| Autor: | Manuela Ernst, Nicolo Cosmelli, Iris Keller, Stephan Zeiter, T. Fintan Moriarty, Tanja Schmid, Wilhelmus Metsemakers, Daniel Arens, R. Geoff Richards |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Humeral Fractures
medicine.medical_specialty Prosthesis-Related Infections Surface Properties 0206 medical engineering education Dentistry chemistry.chemical_element 02 engineering and technology Bacterial Adhesion Fracture Fixation Internal 03 medical and health sciences 0302 clinical medicine In vivo Materials Testing Fracture fixation Bone plate Cadaver medicine Animals Prosthesis-Related Infection General Environmental Science Titanium Colony-forming unit 030222 orthopedics Osteosynthesis business.industry Staphylococcal Infections Stainless Steel 020601 biomedical engineering Surgery Disease Models Animal chemistry General Earth and Planetary Sciences Female Rabbits Implant business Bone Plates |
| Popis: | Introduction Implant-related infection is a challenging complication in musculoskeletal trauma surgery. In the present study, we examined the role of implant material and surface topography as influencing factors on the development of infection in an experimental model of plating osteosynthesis in the rabbit. Methods The implants included in this experimental study were composed of: standard Electropolished Stainless Steel (EPSS), standard titanium (Ti-S), roughened stainless steel (RSS) and surface polished titanium (Ti-P). Construct stability and load-to-failure of Ti-P implants was compared to that of Ti-S implants in a rabbit cadaveric model. In an in vivo study, a rabbit humeral fracture model was used. Each rabbit received one of three Staphylococcus aureus inocula, aimed at determining the infection rate at a low, medium and high dose of bacteria. Outcome measures were quantification of bacteria on the implant and in the surrounding tissues, and determination of the infectious dose 50 (ID50). Results No significant differences were observed between Ti-S and Ti-P regarding stiffness or failure load in the cadaver study. Of the 72 rabbits eventually included in the in vivo study, 50 developed an infection. The ID50 was found to be: EPSS 3.89 × 103 colony forming units (CFU); RSS 8.23 × 103 CFU; Ti-S 5.66 × 103 CFU; Ti-P 3.41 × 103 CFU. Significantly lower bacterial counts were found on the Ti-S implants samples compared with RSS implants (p |
| Databáze: | OpenAIRE |
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