Cerebral venous thrombosis in Behçet’s disease compared to those associated with other etiologies
| Autor: | S. Yılmazer, S. Bahar, Nilufer Yesilot, Rezzan Tuncay, Gulsen Akman-Demir, O. Coban, Melike Mutlu, Murat Kürtüncü |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Comorbidity Behcet's disease Severity of Illness Index Gastroenterology Disability Evaluation Young Adult Internal medicine Severity of illness Aphasia medicine Humans Child Aged Retrospective Studies Venous Thrombosis business.industry Vascular disease Behcet Syndrome Retrospective cohort study Middle Aged medicine.disease Cerebral Veins Surgery Paresis Venous thrombosis Neurology Etiology Female Neurology (clinical) Intracranial Hypertension business Vasculitis |
| Zdroj: | Journal of Neurology. 256:1134-1142 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-009-5088-4 |
| Popis: | Cerebral venous thrombosis (CVT) is caused by various etiologies. In Mediterranean and Middle Eastern countries, Behcet's disease (BD) is one of the leading causes of CVT. We aimed to evaluate any differences in CVT patients with and without BD. All registered patients with CVT were evaluated retrospectively. Clinical, neuroradiological findings and follow-up data were compared between patients with BD and patients with other etiologies. There were 36 patients with CVT and BD, and 32 patients with CVT related to other etiological causes. BD patients were younger (median age at onset 26 vs. 39 years; P < 0.001), and there was a male preponderance (28 males, 8 females) as compared to the non-BD group (10 males, 22 females; P < 0.001). Onset was frequently acute in the non-BD group, and it was subacute or chronic in the BD group. Hemi/quadriparesis, aphasia and seizures were significantly more common (P < 0.001) in the non-BD group. In the BD group 94% of the patients presented with symptoms of isolated intracranial hypertension (P < 0.001). Venous infarcts were observed in 63% of the patients with other causes and in 6% of the patients with BD (P < 0.001). At admission 97% of the patients in the BD group and 41% of the patients in the non-BD group had a modified Rankin score of 0-2. Outcome was good in all of the patients with BD and in 91% of patients with other causes. Clinical recurrences were seen in six patients with BD and in one patient without BD. CVT associated with BD has a subacute onset, mostly presents with signs of isolated intracranial hypertension and venous infarction rarely develops; these features distinguish CVT due to BD from those with other causes. |
| Databáze: | OpenAIRE |
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