Diffusion weighted imaging of the uterus: regional adc variation with oral contraceptive usage and comparison with cervical cancer
| Autor: | Christina Messiou, Thomas Ind, Sonali S. De Silva, Nandita M. deSouza, Veronica A. Morgan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Oral contraceptive pill Population Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Young Adult medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Prospective Studies education Cervix Gynecology Cervical cancer education.field_of_study Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Uterus Magnetic resonance imaging General Medicine medicine.disease body regions Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Female Nuclear medicine business Contraceptives Oral Diffusion MRI |
| Zdroj: | Acta Radiologica. 50:696-701 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1080/02841850902926473 |
| Popis: | Background: There is growing interest in diffusion weighted magnetic resonance imaging (MRI) of cervical carcinoma but normal uterine appearances and effects of the oral contraceptive pill (OCP) have not been described. Purpose: To establish apparent diffusion coefficient (ADC) values for normal regions of uterus, determine the effect of the OCP on these values, and compare them with ADCs from cervical cancer. Material and Methods: Twenty-seven premenopausal women (19 taking the OCP) with cervical intraepithelial neoplasia (CIN) were studied with T2W and diffusion weighted MRI (DW-MRI). Regions of interest were drawn on ADC maps by visual matching with T2W images on different zones of the uterus and values compared between women not taking and taking the OCP. A further group of 25 women with clinically obvious tumors of the cervix were also studied with T2W and DW-MRI and ADC values of tumor were compared with ADC values of cervical epithelium and stroma. Results: The ADC values of adjacent zones of the uterus and cervix were significantly different from one another ( P Conclusion: The zonal anatomy of the uterus is well demonstrated by DW-MRI with hormonal effects secondary to the OCP affecting junctional zone alone. ADC of cervical tumor is significantly different to cervical epithelium and stroma indicating a role in cervical cancer detection and local staging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|