Changes in a CSF Antigen Associated with Dementia
| Autor: | Charles R. Harrington, Claude Michel Wischik, Carretero Mt |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.drug_class Cognitive Neuroscience tau Proteins Monoclonal antibody Central nervous system disease Degenerative disease Cerebrospinal fluid Antigen Alzheimer Disease medicine Humans Dementia Antigens Aged business.industry Antibodies Monoclonal Neurofibrillary Tangles Middle Aged medicine.disease Immunohistochemistry Psychiatry and Mental health Immunology Disease Progression Paired helical filaments Female Geriatrics and Gerontology Alzheimer's disease business |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 6:281-285 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | An 85-kDa antigen was detected in cerebrospinal fluid (CSF) using a monoclonal antibody, 11.57, raised against a fraction of paired helical filaments extracted from Alzheimer’s disease (AD) brain tissues. The antigen is a thermostable protein that is unrelated either to tau or amyloid β-protein precursor. Its level was measured in lumbar and post-mortem CSF samples and found to be decreased significantly in patients with dementia as compared with non-demented controls. There was no difference in its level between patients with AD and those with non-Alzheimer type dementia. In AD, however, there was a significant relationship between disease progression and the amount of the 85-kDa antigen. |
| Databáze: | OpenAIRE |
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