Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age
| Autor: | Pan Yang, Jie Wang, Ao-Bo Hong, Li-Li Huang, Qi-Tong Xie, Yi-Xin Wang, Cheng-Liang Xiong, Tian-Qing Meng, An Pan, Da Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Male
China Environmental Engineering Health Toxicology and Mutagenesis Reproduction Public Health Environmental and Occupational Health Phthalic Acids General Medicine General Chemistry Cosmetics Environmental Exposure Pollution Environmental Chemistry Cluster Analysis Humans Environmental Pollutants Life Style |
| Zdroj: | Chemosphere. 299 |
| ISSN: | 1879-1298 |
| Popis: | Personal care products, such as additives, have raised widespread concerns about the potential threat to male reproductive health. The spermatogenesis in humans lasts for approximately 90 days, the average levels of these chemicals remain unclear during spermatogenesis. In our study, we pooled urine samples from each man during the days of 1-15, 16-31, 32-63, and ≥64, and examined exposure to 48 typical additive chemicals. By principal component analysis (PCA), k-means clustering, and Spearman's rank correlations, we then identified 6 PC scores and 4 clusters based on profiles of these chemicals. Some industrial, commercial or structural similar chemicals (e.g., phthalates) were significantly correlated compared to unrelated chemicals (e.g., benzophenone). PCA scores were associated with individual lifestyles (e.g., household income, tea consumption, and drinking tap water). Distinct exposure components and exposure patterns of personal care products may help the reproductive health assessment of men. We suggested more concerns for widespread exposure to these chemicals for men. |
| Databáze: | OpenAIRE |
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