Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)
| Autor: | Peter M. J. Burgers, Elias Tannous |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Saccharomyces cerevisiae Proteins
DNA damage Cell Cell Cycle Proteins Ataxia Telangiectasia Mutated Proteins Biology Protein Serine-Threonine Kinases Biochemistry Article 03 medical and health sciences Chromosome instability medicine Humans Kinase activity Molecular Biology 030304 developmental biology 0303 health sciences Mechanism (biology) Kinase 030302 biochemistry & molecular biology Cell Cycle DNA replication Intracellular Signaling Peptides and Proteins Cell cycle Cell biology medicine.anatomical_structure DNA Damage |
| Zdroj: | Crit Rev Biochem Mol Biol |
| Popis: | DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability of precursors and improper chromosome alignment. When these problems are not addressed, they may lead to chromosome instability and the accumulation of mutations, and even cell death. Therefore, the cell has developed response mechanisms to keep most of these situations under control. Of the many factors that participate in this DNA damage response, members of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), orchestrate the response landscape. Our understanding of two members of the PIKK family, human ATR (yeast Mec1) and ATM (yeast Tel1), and their associated partner proteins, has shown substantial progress through recent biochemical and structural studies. Emerging structural information of these unique kinases show common features that reveal the mechanism of kinase activity. |
| Databáze: | OpenAIRE |
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