Cell sheet transplantation prevents inflammatory adhesions: A new treatment for adhesive otitis media
| Autor: | Shun Kikuchi, Hiromi Kojima, Manabu Komori, Masayuki Yamato, Tsunetaro Morino, Kazuhisa Yamamoto, Yoshiyuki Kasai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) medicine.medical_treatment Biomedical Engineering Adhesion (medicine) Computed tomography Biomaterials Tympanoplasty R5-920 Medicine Tympanic cavity Adhesive otitis media Cell sheet medicine.diagnostic_test QH573-671 business.industry Cell sheet transplantation medicine.disease Mucosal regeneration Surgery Transplantation medicine.anatomical_structure Middle ear Adhesion Original Article business Cytology Developmental Biology |
| Zdroj: | Regenerative Therapy, Vol 18, Iss, Pp 457-463 (2021) Regenerative Therapy |
| ISSN: | 2352-3204 |
| Popis: | Introduction: We developed a new treatment method that combines tympanoplasty with transplantation of autologous cultured nasal mucosal epithelial cell sheets to regenerate the mucosa of patients with adhesive otitis media, which has been difficult to treat effectively. We verified whether this procedure could be performed safely and measured its therapeutic efficacy. Methods: Autologous nasal mucosal epithelial cell sheets were manufactured at a good manufacturing practice-compliant cell processing facility using autologous nasal mucosal tissue. We performed tympanoplasty and transplanted the cell sheets into the middle ear cavity in six patients with adhesive otitis media. Results: The manufactured autologous cultured epithelial cell sheets met the predetermined quality standards and were successfully transplanted safely in all cases. Computed tomography findings after cell sheet transplantation showed that aeration in the tympanic cavity was maintained or restored in five of the six patients (83.3%). Four of the six (66.7%) patients had postoperative air-bone gap within 20 dB, which is considered a postoperative success in tympanoplasty for chronic middle ear disease. Conclusions: The results of this clinical study suggest that tympanoplasty with cell sheet transplantation can be used to treat adhesive otitis media by reliably preventing re-adhesion of the tympanic membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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