Causative Links between Protein Aggregation and Oxidative Stress: A Review

Autor: Elise Lévy, Dorothée Baïlle, Amélie Heneman-Masurel, Vincent Béringue, Davy Martin, Laurence Vernis, Meng-Er Huang, Nadine El Banna, Sandrine Truchet, Human Rezaei
Přispěvatelé: Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Intégrité du génome, ARN et cancer, Institut Curie [Paris]-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Unité de recherche Virologie et Immunologie Moléculaires (VIM), Stress génotoxiques et cancer, Université Paris-Sud - Paris 11 (UP11)-Institut Curie-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Paris-Sud - Paris 11 (UP11), Vernis, Laurence
Jazyk: angličtina
Rok vydání: 2019
Předmět:
[SDV]Life Sciences [q-bio]
[SDV.CAN]Life Sciences [q-bio]/Cancer
Oxidative phosphorylation
Computational biology
Disease
Review
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Protein aggregation
medicine.disease_cause
Protein Aggregation
Pathological
Catalysis
Prion Diseases
protein aggregation
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
Protein Aggregates
0302 clinical medicine
Alzheimer Disease
medicine
proteinopathy
Animals
Humans
oxidative stress
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
redox
Organic Chemistry
Proteins
Parkinson Disease
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
General Medicine
Computer Science Applications
lcsh:Biology (General)
lcsh:QD1-999
030217 neurology & neurosurgery
Oxidative stress
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (16), pp.3896. ⟨10.3390/ijms20163896⟩
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3896 (2019)
International Journal of Molecular Sciences 16 (20), . (2019)
ISSN: 1661-6596
1422-0067
DOI: 10.3390/ijms20163896⟩
Popis: International audience; Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer's disease, Parkinson's disease, and prion disease. The literature is tremendously rich in studies that establish a functional link between both processes, revealing that oxidative stress can be either causative, or consecutive, to protein aggregation. Because oxidative stress monitoring is highly challenging and may often lead to artefactual results, cutting-edge technical tools have been developed recently in the redox field, improving the ability to measure oxidative perturbations in biological systems. This review aims at providing an update of the previously known functional links between oxidative stress and protein aggregation, thereby revisiting the long-established relationship between both processes.
Databáze: OpenAIRE
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