In Vivo Confocal Microscopic Evaluation of the Limbus and Cornea in Vogt Koyanagi Haradas Syndrome

Autor:	Gowri Priya Chidambaranathan, Radhika Thundikandy, Rathinam, Naveen Radhakrishnan
Rok vydání:	2021
Předmět:	medicine.medical_specialty Microscopy Confocal business.industry Confocal Epithelium Corneal Cell Count Limbus Corneae eye diseases Cornea Ophthalmology medicine.anatomical_structure In vivo medicine Humans Immunology and Allergy sense organs business
Zdroj:	Ocular Immunology and Inflammation. 30:1361-1368
ISSN:	1744-5078 0927-3948
DOI:	10.1080/09273948.2021.1873395
Popis:	To elucidate the microarchitecture of limbus and cornea in subjects with Vogt Koyanagi Haradas syndrome (VKH).From January 2019 to December 2019 a total of 17 VKH subjects, 5 acute and 12 chronic, 18 non VKH uveitis controls, and 6 healthy controls were recruited for this study . In vivo confocal microscopic (IVCM) analysis of the limbal basal epithelium, scleral side of the limbus, limbal niche, corneal keratocytes, and corneal nerves was carried out .Absence of pigmented cells in the limbal basal epithelium, presence of inflammatory cells on the scleral side of the limbus, fibrotic niche, degenerated keratocytes, thinning, and beading of corneal nerves were noted in VKH eyes as compared to controls.Presence of inflammatory cells and depigmentation of limbus in chronic VHK points to disease progression.Keratocyte and corneal nerve changes in Vogt Koyanagi Haradas syndrom are novel findings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d481f638833d323d92b43104f56d113 https://doi.org/10.1080/09273948.2021.1873395 Zobrazit plný text záznamu