Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe

Autor: De Luca, A, Dunn, D, Zazzi, M, Camacho, R, Torti, C, Fanti, I, Kaiser, R, Sönnerborg, A, Codoñer, Fm, Van Laethem, K, Vandamme, Am, Bansi, L, Ghisetti, V, van de Vijver DA, Asboe, D, Prosperi, Mc, Di Giambenedetto, S, Collaborators: Giacometti A, SEHERE collaboration in C. h. a. i. n., Butini, L, del Gobbo, R, Menzo, S, Tacconi, D, Corbelli, G, Zanussi, S, Monno, L, Punzi, G, Maggiolo, F, Callegaro, A, Calza, L, Pristerà, R, Turconi, P, Mandas, A, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Corsi, P, Galli, L, Di Pietro, M, Bartalesi, F, Colao, G, Tosti, A, Di Biagio, A, Setti, M, Bruzzone, B, Penco, G, Trezzi, M, Orani, A, Pardelli, R, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, Monforte, Ad, Cicconi, P, Rusconi, S, Gismondo, Mr, Micheli, V, Biondi, Ml, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Pecorari, M, Soria, A, Vecchi, L, Santirocchi, M, Brustia, D, Ravanini, P, Dal Bello, F, Romano, N, Mancuso, S, Calzetti, C, Maserati, R, Filice, G, Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, Rita
Přispěvatelé: De Luca, A, Dunn, D, Zazzi, M, Camacho, R, Torti, C, Fanti, I, Kaiser, R, Sönnerborg, A, Codoñer, F, Van Laethem, K, Vandamme, A, Bansi, L, Ghisetti, V, Van De Vijver, D, Asboe, D, Prosperi, M, Di Giambenedetto, S, Mancuso, S, Virology
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Multivariate analysis
Databases
Factual
Drug Resistance
HIV Infections
Drug resistance
0302 clinical medicine
Retrospective Studie
Risk Factors
Epidemiology
Genotype
pol Gene Products
Human Immunodeficiency Viru
Odds Ratio
Prevalence
Immunology and Allergy
HIV Infection
030212 general & internal medicine
pol Gene Products
Viral
Multivariate Analysi
media_common
0303 health sciences
Drug Resistance Prevalence HIV-1
Middle Aged
Resistance mutation
3. Good health
Reverse Transcriptase Inhibitor
Europe
Infectious Diseases
Reverse Transcriptase Inhibitors
epidemiology
Female
Multiple
Human Immunodeficiency Virus
Human
Drug
Adult
medicine.medical_specialty
Evolution
media_common.quotation_subject
Sexual Behavior
antiretroviral therapy
Infectious Disease
Biology
Settore MED/17 - MALATTIE INFETTIVE
Evolution
Molecular
03 medical and health sciences
Databases
SDG 3 - Good Health and Well-being
Drug Resistance
Multiple
Viral
medicine
Humans
HIV Protease Inhibitor
Factual
Retrospective Studies
030306 microbiology
Risk Factor
Molecular
Retrospective cohort study
Odds ratio
HIV Protease Inhibitors
CD4 Lymphocyte Count
drug resistance
genotyping
HIV-1
Multivariate Analysis
Mutation
pol Gene Products
Human Immunodeficiency Virus
Immunology
Demography
Zdroj: Journal of Infectious Diseases; Vol 207
Journal of Infectious Diseases
Journal of Infectious Diseases, 207(8), 1216-1220. Oxford University Press
ISSN: 0022-1899
DOI: 10.1093/infdis/jit017
Popis: HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis. © 2013 The Author.
Databáze: OpenAIRE
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